世界最杰出的生物医学论文

千名生物学家（Faculty of 1000 Biology）和千名医学家（Faculty of 1000 Medicine）是英国BioMed Central出版集团，所建立的两个医学生物学论文数据库。它是由美国哈佛大学和英国剑桥大学等近5000多名世界顶级生物医学同行专家，所推荐和评选出的世界医学和生物学的最新发表的论文所组成。

论文依据创新性、新理论、新发现、新技术、科学价值和实际应用前景等原则，从世界上几千种重要的医学生物学杂志，成千上万篇论文中，实时进行筛选和评定，评选出F1000因子，并进行分级排序，分为杰出(Exceptional 9分)、必读(Must Read 6分)和推荐(Recommend 3分)三个级别，并写有简短的评语。再向医学生物学界进行推荐和发布，以提供世界上最重要、最优秀的生物医学论文信息和最新研究成果与发展趋势。

F1000只重视论文的实际科学价值和临床应用前景，不考虑期刊的状况和论文在何处发表，影响因子（I F）值也仅仅作为辅助参考指标。被推荐出的论文不足SCI发表论文的千分之二，其中杰出的论文仅占所推荐论文的5%。F1000还依据不同的科学领域，适时评选出最近和最受关注（Must-Viewed）的10篇最佳论文，称为“Top 10”，并不断更新。此外还邀请世界上最知名和权威的领域科学家，编写生物医学最近的进展、评论和综述，刊登在“F1000 Reports上”。

F1000是一个新的医学生物学论文数据库，是一个新的生物医学论文评价工具，是一个新的医学论文评估的专家系统。它不仅可以帮助我们来快速检索世界上最“杰出”、“必须阅读”和“值得推荐”的生物医学论文；还可以了解每篇发表论文的专家评价观点和意见，使我们可以节时、高效、全面认识和了解当今世界上生物医学最新研究成果和发展动向，引导和促进生物医学科学的发展。研究论文能为F1000所收录和推荐，成为F1000“杰出”论文，代表着该论文的极高的科学水平和重要的科学价值。

目前我国每年被SCI收录的医学生物学论文已逾万篇，成为“论文大国”，但能为F1000收录为“杰出”的论文却寥寥。以2009—2010年为例，在F1000收录和推荐出1017篇“杰出”论文中，中国只有11篇，其中还有4篇是和的。从2000—2010年F1000共评出近5000篇“杰出”论文，中国（包括和）总共只有25有篇。反应出我国现在医学生物学研究“跟”多“创”少，重“量”不重“质” ；一般资料性的工作多，有创新性、有实际应用价值、有重要理论和应用前景的论文少的潜在而深刻的危机。

我们必须在原始创新和实际应用上再上一层楼！我们要发表SCI论文，要发表高IF影响因子论文；我们更要多发表F1000“杰出”论文，发表创新性强，有重要理论价值和实际应用前景的科学论文，这才能成为真正的科技强国。

这里我们收集了2009－2010年心血管、肿瘤、细胞生物学、分子生物学、免疫学、神经科学等领域F1000的“杰出”论文供大家参考，更多的F1000论文，可在F1000Biology和F1000Medicine网站上搜索。

• Biochemistry • Bioinformatics • Biotechnology • Cancer Biology • Cardiovascular Biology • Cell Biology • Chemical Biology • Developmental Biology • Ecology

• Evolutionary Biology • Gastrointestinal Biology • Genomics & Genetics

• Immunology

• Metabolic & Endocrine Science • Microbiology • Molecular Biology • Molecular Medicine • Neuroscience

• Pharmacology & Drug Discovery • Physiology • Plant Biology • Renal Biology • Respiratory Biology • Structural Biology

• Anesthesiology & Pain Management • Cardiovascular Disorders

• Critical Care & Emergency Medicine • Dermatology

• Diabetes & Endocrinology • Gastroenterology & Hepatology • Hematology • Infectious Diseases • Nephrology

• Neurological Disorders • Oncology • Otolaryngology • Psychiatry

• Public Health & Epidemiology • Research Methodology • Respiratory Disorders

• Rheumatology & Clinical Immunology • Urology • Women's Health

________________________________________ F1000 Report

cell-A mover and a shaker'- 53BP1 allows DNA doublestrand breaks a chance to dance and unite cell-A virtual cycle- theory and experiment converge on the exit from mitosis cell-Aberrant mRNA transcripts and nonsense-mediated decay

cell-Autophagy of intracellular microbes and mitochondria- two sides of the same coin

cell-Brd4 engagement from chromatin targeting to transcriptional regulation- selective contact with acetylated histone H3 and H4

cell-Conformational changes in receptor tyrosine kinase signaling- an ErbB garden of delights cell-Destroy to create- E3 ubiquitin ligases in neurogenesis

cell-Doing cell biology in embryos- regulated membrane traffic and its implications for cadherin biology cell-Epigenetic regulation of antigen receptor gene rearrangement

cell-G-protein-coupled receptor structure

cell-Induced pluripotent stem (iPS) cells- an up-to-the-minute review

cell-Inhibitor of Apoptosis (IAP) proteins as drug targets for the treatment of cancer cell-Intracellular trafficking and signaling in development cell-LOV conquers (sm)All GTPases cell-Membrane deformation and separation

cell-Microtubule motors- moving forward on many fronts cell-Mitochondria and apoptosis- a quick take on a long view

cell-novel functions of the exocyst complex in polarized epithelia in animals

cell-PARP inhibitors in BRCA1-BRCA2 germline mutation carriers with ovarian and breast cancer cell-Plk4-SAK-ZYG-1 in the regulation of centriole duplication cell-Putative functions of caspase-2

cell-Recent advances in polyubiquitin chain recognition cell-Recent advances in understanding Golgi biogenesis cell-Regulatory roles of the cadherin superfamily

cell-Role of caspases and non-caspase proteases in cell death cell-Roles of AD-cofilin in actin polymerization and beyond cell-Roles of the small GTPases RhoA and Rac1 in cell behavior cell-Single-molecule dynamics of nuclear mRNA

cell-Spindle checkpoint silencing- ensuring rapid and concerted anaphase onset cell-Telomeric RNAs as a novel player in telomeric integrity

cell-The roles, mechanisms, and controversies of autophagy in mammalian biology cell-Transport vesicle uncoating- it's later than you think

cell-Understanding lipid rafts and other related membrane domains

cell-Vesicle coating and uncoating- controlling the formation of large COPII-coated carriers cell-When transcription meets recombination

ecology-Characterizing changes in marine ecosystem services

ecology-Climate change and biodiversity conservation- impacts, adaptation strategies and future research directions

ecology-Current themes and recent advances in modelling species occurrences

ecology-Eco-evolutionary dynamics- intertwining ecological and evolutionary processes in contemporary time ecology-Evaluation of global change impacts on diffuse pollution ecology-Evolutionary impacts of fishing

ecology-Extinction risks from climate change- macroecological and historical insights Ecology-Modelling ecosystem services in terrestrial systems

ecology-The consequences of human-driven ocean acidification for marine life ecology-Toward understanding the effect of top predators on ecosystems genome-A direct measurement of crossing over in human prophase oocytes genome-Advances in the genetics of primary torsion dystonia

genome-Applications of high-throughput sequencing to chromatin structure and function in mammals genome-Bioinformatic detection of horizontally transferred DNA in bacterial genomes genome-CRISPR-Cas- an adaptive immunity system in prokaryotes

genome-Distinct disorders affecting the brain share common genetic origins genome-Emerging technologies for the genomic analysis of cancer

genome-Genetics of pulmonary arterial hypertension- do the molecular findings have translational value- genome-Hidden ribozymes in eukaryotic genome sequence

genome-how medical sequencing and network biology will enable personalized medicine genome-Insulators- linking genome architecture to gene regulation genome-Mapping chromatin conformation genome-Pharmacogenetics of osteoporosis

genome-PRDM9 sticks its zinc fingers into recombination hotspots and between species genome-Prediction of function in protein superfamilies

genome-RecA-independent single-stranded DNA oligonucleotide-mediated mutagenesis genome-Recent advances in RNA sequence analysis

genome-Retrotransposons and germ cells- reproduction, death, and diversity genome-The application of massively parallel sequencing technologies

genome-Ubiquitous antisense transcription in eukaryotes- novel regulatory mechanism or byproduct of opportunistic -NA polymerase

genome-When transcription meets recombination- a lesson from the human RECQ protein complexes imm-Antigen processing for MHC presentation by autophagy

imm-inf-A novel mucosal RORt+NKp46+ cell subset is a source of interleukin-22

imm-inf-Advances in understanding the interaction between the gut microbiota and adaptive mucosal immune responses

imm-inf-Alternative macrophage activation and the regulation of metabolism

imm-inf-An update on pathobiologic roles of anti-glycan antibodies in Guillain-Barr茅 syndrome imm-inf-B cell-targeted therapies in autoimmunity- rationale and progress imm-inf-Bacterial surface proteins and vaccines

imm-inf-Do apicomplexan parasite-encoded proteins act as both ligands and receptors during host cell invasion imm-inf-Do apicomplexan parasites hijack the host cell microRNA pathway for their intracellular development imm-inf-Duality in the Th17-Treg developmental decision

imm-inf-Electron transport chains of lactic acid bacteria - walking on crutches is part of their lifestyle imm-inf-Genetic reprogramming of host cells by bacterial pathogens imm-inf-Gut commensal flora- tolerance and homeostasis

imm-inf-HIV vaccination- turning the spotlight on effector memory T cells as mucosal gatekeepers imm-inf-HIV-1 host interactions- integration of large-scale datasets imm-inf-Latest advances in innate antiviral defence

imm-inf-Lessons from the failure of the adenovector HIV vaccine imm-inf-New templates for HIV-1 antibody-based vaccine design imm-inf-Ocular immune privilege

imm-inf-Recent insights into fatty acid acquisition and metabolism in malarial parasites imm-inf-Recent strategies to identify broadly neutralizing antibodies against influenza A virus imm-inf-Regulation of the IgE response imm-inf-The garden of antimicrobial delights

imm-inf-The inflammasome and alum-mediated adjuvanticity

imm-inf-The role of microbial polysaccharides in host-pathogen interaction imm-inf-Thymic egress- S1P of 1000

imm-inf-Two mechanisms that account for major histocompatibility complex restriction of T cells imm-inf-Why is Pseudomonas aeruginosa a pathogen

imm-The role of IL-23 in the immunopathogenesis of psoriasis ns-A current view of Alzheimer's disease ns-An uncorrelated state for the cortex

ns-channelopathies- new antibody-mediated disorders of the central nervous system ns-Control of Schwann cell myelination ns-De novo prions

ns-Development of object recognition in humans

ns-Dysfunction of the CaV2.1 calcium channel in cerebellar ataxias ns-E3 ubiquitin ligases in neurogenesis ns-mechanotransduction in inner-ear hair cells ns-Multiple functions of dopamine neurons ns-Music drives brain plasticity ns-Neuronal calcium sensor proteins ns-Recent advances in neural development ns-Seeing with the mind's eye

ns-Setting the absolute threshold of vision

ns-Sources of the spatial code within the hippocampus

ns-The growth cone- an integrator of unique cues into refined axon guidance ns-The posterior parietal cortex and non-spatial cognition

ns-Transcranial magnetic stimulation studies of visuospatial attentional control ns-What drives corticospinal output

ns-Why do oligodendrocyte lineage cells express glutamate receptors

physiol-'Functional' body composition- differentiating between benign and non-benign obesity physiol-Biased agonism

physiol-Bitopic ligands- all-in-one orthosteric and allosteric physiol-Central control of feeding

physiol-Depression and metabolism- linking changes in leptin and ghrelin to mood physiol-Malarial parasite pathogenesis and drug targets physiol-Multiple functions of dopamine neurons physiol-New antibiotics for antibiotic-resistant bacteria physiol-pharmacol-The pathophysiology of diastolic heart failure physiol-Purinergic cotransmission

physiol-Regulation of the mTOR signaling pathway

physiol-Role of neuropeptides, hormones, and growth factors in regulating thymopoiesis in middle to old age physiol-Stress and eating behaviour

physiol-Targeting cytokines in inflammatory diseases

physiol-The ABCB1 transporter gene and antidepressant response physiol-The evolving story of orexin biology- the hits keep coming physiol-TRPV4 as a target for bladder overactivity physiol-Using the ribosome to synthesize peptidomimetics structural biology-Biased agonism

structural biology-Describing protein conformational ensembles

structural biology-Detailed mechanism for transposition by TnpA transposase involves DNA -shape rather than direct protein-DNA recognition to generate an active nucleoprotein complex

structural biology-Diversity of protein structures and difficulties in fold recognition-the curious case of protein G structural biology-Implications of the RecA structure

structural biology-Mechanistic and functional versatility of radical SAM enzymes structural biology-Membrane deformation and separation

structural biology-Molecular dynamics-based approaches for enhanced sampling of long-time, large-scale conformational changes in biomolecules

structural biology-Monte Carlo, harmonic approximation, and coarse-graining approaches for enhanced sampling of biomolecular structure

structural biology-Nuclear magnetic resonance captures the elusive structural biology-Osmolyte solutions and protein folding

structural biology-protein conformation and the ubiquitination reaction cascade structural biology-Recent advances in polyubiquitin chain recognition structural biology-RNA pseudoknots-folding and finding structural biology-Structure of spliceosomal ribonucleoproteins structural biology-The unforeseeable hammerhead ribozyme

structural biology-Understanding lipid rafts and other related membrane domains structural biology-Unnatural amino acids- better than the real things F1000 Top 10

bi-A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury bi-Cell line misidentification- the beginning of the end

bi-Chaperonin-dependent accelerated substitution rates in prokaryotes

bi-Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model bi-Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis bi-High-resolution analysis of parent-of-origin allelic expression in the mouse brain

bi-Long-timescale molecular-dynamics simulations of the major urinary protein provide atomistic interpretations of the unusual thermodynamics of ligand binding

bi-Mammalian microRNAs predominantly act to decrease target mRNA levels bi-Robust Growth of Escherichia coli

bi-Sex-specific parent-of-origin allelic expression in the mouse brain

bi-Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy

bi-The genetic landscape of a cell

biochem-Functional modules and structural basis of conformational coupling in mitochondrial complex I biochem-In Vivo Double and Triple Labeling of Proteins Using Synthetic Amino Acids biochem-One SNARE complex is sufficient for membrane fusion

biochem-Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy biochem-Robust Growth of Escherichia coli

biochem-Self-confirming AND logic nanoparticles for fault-free MRI

biochem-Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy

biochem-Structure of RCC1 chromatin factor bound to the nucleosome core particle

biochem-Structure of the torque ring of the flagellar motor and the molecular basis for rotational switching biochem-The architecture of respiratory complex I

biochem-The functional capacity of the natural amino acids for molecular recognition

biochem-Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

biology-Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine biology-An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis biology-Astrocytes control breathing through pH-dependent release of ATP biology-Chaperonin-dependent accelerated substitution rates in prokaryotes

biology-Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

biology-Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension

biology-MiR-33 contributes to the regulation of cholesterol homeostasis biology-Neuroscience and the correct level of explanation for understanding mind

biology-Role of secondary sensory cortices in emotional memory storage and retrieval in rats biology-Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer biology-TGF-beta signaling specifies axons during brain development

biology-The Amphimedon queenslandica genome and the evolution of animal complexity biology-The coevolution of human hands and feet

biotech-Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5

biotech-Exploiting the determinants of stochastic gene expression in Saccharomyces cerevisiae for genome-wide prediction of expression noise

biotech-Fragment-based drug discovery applied to hsp90. Discovery of two lead series with high ligand efficiency biotech-Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis biotech-Metabolomic and transcriptomic stress response of Escherichia coli biotech-Sex-specific parent-of-origin allelic expression in the mouse brain biotech-Small-molecule inducers of insulin expression in pancreatic {alpha}-cells

biotech-Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy

biotech-The genetic landscape of a cell

biotech-Type IIA topoisomerase inhibition by a new class of antibacterial agents

ca-A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution ca-Allogeneic hematopoietic cell transplantation for hematological malignancy

ca-An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein ca-Cdc14- a highly conserved family of phosphatases with non-conserved functions ca-Early palliative care for patients with metastatic non鈥搒mall-cell lung cancer

ca-Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes- a randomised, open-label, phase III study

ca-Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma

ca-Hematopoiesis in three dimensions- human and murine bone marrow architecture visualized by confocal microscopy

ca-Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis ca-IFNalpha activates dormant haematopoietic stem cells in vivo

ca-Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

ca-Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

ca-Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells

ca-Mdm2 facilitates the association of p53 with the proteasome

ca-Methylation of H3K4 Is required for inheritance of active transcriptional states

ca-NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein

ca-Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7

ca-Pitfalls in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors

ca-PML targeting eradicates quiescent leukaemia-initiating cells

ca-Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase ca-Radical cystectomy in octogenarians--does morbidity outweigh the potential survival benefits

ca-Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab

ca-Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen ca-strategies primary care physicians use to deny patient requests

ca-Structural basis for negative cooperativity in growth factor binding to an EGF receptor ca-Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B ca-The epithelial-mesenchymal transition generates cells with properties of stem cells ca-Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model

ca-Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity

ca-Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network cell-A minimal midzone protein module controls formation and length of antiparallel microtubule overlaps cell-Branched tricarboxylic acid metabolism in Plasmodium falciparum

cell-C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel cell-Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

cell-Collective chemotaxis requires contact-dependent cell polarity

cell-Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography cell-Functionally defective germline variants of sialic acid acetylesterase in autoimmunity cell-Global analysis of trans-splicing in Drosophila

cell-Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis cell-MiR-33 contributes to the regulation of cholesterol homeostasis cell-Segregation of yeast nuclear pores

cv-A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis

cv-A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response

cv-Age-related changes in the sympathetic innervation of cerebral vessels and in carotid vascular responses to norepinephrine in the rat- in vitro and in vivo studies

cv-Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5

cv-Cardiovascular and cancer mortality in very elderly post-myocardial infarction patients receiving statin treatment.-

cv-Cardiovascular and cancer mortality in very elderly post-myocardial infarction patients receiving statin treatment

cv-Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary

syndromes (PLATO)-a randomised double-blind study

cv-Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates cv-Dabigatran versus warfarin in patients with atrial fibrillation

cv-Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors cv-Effect of calcium supplements on risk of myocardial infarction and cardiovascular events- cv-Effect of calcium supplements on risk of myocardial infarction and cardiovascular events cv-Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes cv-Effects of intensive blood-pressure control in type 2 diabetes mellitus

cv-Enalapril in infants with single ventricle- results of a multicenter randomized trial cv-Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression cv-Identification of a Kir3.4 mutation in congenital long QT syndrome- cv-Identification of a Kir3.4 mutation in congenital long QT syndrome cv-Impact of lipid-lowering therapy on outcomes in atrial fibrillation

cv-Inhibiting mitochondrial fission protects the heart against ischemia-reperfusion injury

cv-Involvement of reductive stress in the cardiomyopathy in transgenic mice with cardiac-specific overexpression of heat shock protein 27

cv-Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation

cv-Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism-

cv-Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism

cv-Maintenance of sinus rhythm and survival in patients with heart failure and atrial fibrillation cv-Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5

cv-MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis cv-Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

cv-Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes cv-Renal and retinal effects of enalapril and losartan in type 1 diabetes

cv-Results of the randomized, placebo-controlled clopidogrel and acetylsalicylic acid in bypass surgery for peripheral arterial disease (CASPAR) trial

cv-Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome

cv-Stenting versus endarterectomy for treatment of carotid-artery stenosis

cv-Sustained suppression of sympathetic activity and arterial pressure during chronic activation of the carotid baroreflex

cv-Telemonitoring and self-management in the control of hypertension (TASMINH2) cv-Telmisartan, ramipril, or both in patients at high risk for vascular events

ecology-A global network of coexisting microbes from environmental and whole-genome sequence data ecology-Competition limits adaptation and productivity in a photosynthetic alga at elevated CO2 ecology-Ecosystem response to elevated CO(2) levels limited by nitrogen-induced plant species shift ecology-Local adaptation and the evolution of species' ranges under climate change ecology-Parasite prevalence and the worldwide distribution of cognitive ability ecology-Promiscuity and the evolutionary transition to complex societies ecology-Statistical inference for noisy nonlinear ecological dynamic systems

ecology-The quantitative genetics of phenotypic robustness genome-cell line misidentification

genome-Chaperonin-dependent accelerated substitution rates in prokaryotes genome-Chromosome size differences may affect meiosis and genome size

genome-Common SNPs explain a large proportion of the heritability for human height genome-Dissecting cancer through mathematics- from the cell to the animal model genome-Global analysis of trans-splicing in Drosophila

genome-High-resolution analysis of parent-of-origin allelic expression in the mouse brain

genome-Inaugural Article- Fast live simultaneous multiwavelength four-dimensional optical microscopy genome-Segregation of yeast nuclear pores

genome-Statistical design and analysis of RNA sequencing data genome-The coevolution of human hands and feet genome-The genetic landscape of a cell

genome-Trans-acting small RNA determines dominance relationships in Brassica self-incompatibility imm-A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis imm-Activation of a metabolic gene regulatory network downstream of mTOR complex 1

imm-An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis imm-Duration of antibiotic therapy in hospitalised patients with community-acquired pneumonia imm-Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse imm-Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection imm-Evidence of dysregulation of dendritic cells in primary HIV infection

imm-Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

imm-Glutamine uptake and metabolism are coordinately regulated by ERK-MAPK during T lymphocyte activation imm-IgT, a primitive immunoglobulin class specialized in mucosal immunity imm-Immature Dengue Virus

imm-Lipid accumulation and dendritic cell dysfunction in cancer

imm-Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

imm-Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression imm-Novel Treponema pallidum Serologic Tests

imm-Patient safety culture- factors that influence clinician involvement in patient safety behaviours

imm-Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

imm-Prolonged infectiousness of tuberculosis patients in a directly observed therapy short-course program with standardized therapy

imm-Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1 imm-Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing

imm-Standard versus newer antibacterial agents in the treatment of severe acute exacerbation of chronic obstructive pulmonary disease

imm-Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01 imm-The latest threat in the war on antimicrobial resistance

imm-Transgenic mice with a diverse human T cell antigen receptor repertoire mol biol-A split active site couples cap recognition by Dcp2 to activation

mol biol-Antisense oligonucleotides and spinal muscular atrophy

mol biol-Fast live simultaneous multiwavelength four-dimensional optical microscopy mol biol-Global analysis of trans-splicing in Drosophila

mol biol-Nonsense-mediated mRNA decay maintains translational fidelity by limiting magnesium uptake mol biol-Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase

mol biol-Replication stress checkpoint signaling controls tRNA gene transcription mol biol-Segregation of yeast nuclear pores

mol biol-Structure of the RNA Binding Domain of a DEAD-Box Helicase Bound to Its Ribosomal RNA Target Reveals a Novel Mode of Recognition by an RNA Recognition Motif

mol biol-Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice mol med-Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine mol med-Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5 mol med-Astrocytes control breathing through pH-dependent release of ATP mol med-Depression can be measured in the eye of the diseased

mol med-Dissecting cancer through mathematics- from the cell to the animal model

mol med-Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension

mol med-Functionally defective germline variants of sialic acid acetylesterase in autoimmunity mol med-Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

mol med-Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry mol med-Transition to addiction is associated with a persistent impairment in synaptic plasticity

ns-Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior

ns-Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage- a systematic review of published and unpublished studies

ns-Astrocytes control breathing through pH-dependent release of ATP

ns-C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel ns-cv-Effects of intensive blood-pressure control in type 2 diabetes mellitus ns-cv-Stenting versus endarterectomy for treatment of carotid-artery stenosis

ns-Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer's Disease Mouse Models ns-Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes ns-Dysregulation of regional endogenous opioid function in borderline personality disorder ns-Exome sequencing identifies the cause of a mendelian disorder

ns-Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

ns-Neuroscience and the correct level of explanation for understanding mind. An extraterrestrial roams through some neuroscience laboratories and concludes earthlings are not grasping how best to understand the mind-brain interface

ns-Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS) ns-Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry ns-Role of secondary sensory cortices in emotional memory storage and retrieval in rats

ns-Sustained suppression of sympathetic activity and arterial pressure during chronic activation of the carotid baroreflex

ns-TGF-beta signaling specifies axons during brain development

ns-Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke ns-We must face the threats

ns-Web-based, participant-driven studies yield novel genetic associations for common traits physiol-Astrocytes control breathing through pH-dependent release of ATP

physiol-Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

physiol-Dissecting cancer through mathematics- from the cell to the animal model

physiol-Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization

physiol-Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension

physiol-Identification of the switch in early-to-late endosome transition

physiol-Melanopsin-expressing retinal ganglion-cell photoreceptors- cellular diversity and role in pattern vision physiol-Mitochondrial GLUT10 Facilitates Dehydroascorbic Acid Import and Protects Cells Against Oxidative stress physiol-Parallel processing of visual space by neighboring neurons in mouse visual cortex

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